Abstract Panel germline testing allows for the efficient detection of deleterious variants for multiple conditions, but the benefits and harms of identifying these variants are not always well understood.We present a multi-gene, multi-disease aggregate utility formula that allows the user to consider adding or removing each gene in a panel based on
Early diagnosis and effective management of Primary immunodeficiency diseases (PIDs), particularly severe combined immunodeficiency (SCID), play a crucial role in minimizing associated morbidities and mortality.Newborn screening (NBS) serves as a valuable tool in facilitating these efforts.Timely detection and diagnosis are essential for swiftly im
Replication studies on human Safety Goggles immunodeficiency virus 1 (HIV-1) rely on a few laboratory strains that are divergent from dominant HIV-1 subtypes in the epidemic.Several phenotypic differences between diverse HIV-1 isolates and subtypes could affect vaccine development and treatment, but this research field lacks robust cloning/virus pr
Mayaro (MAYV) is an emerging arthropod-borne virus belonging to the Alphavirus genus of the Togaviridae family.Although forest-dwelling Haemagogus mosquitoes have been considered as its main vector, the virus has also been detected in circulating Aedes ssp mosquitoes.Here we assess the susceptibility of Aedes aegypti and Aedes albopictus to infecti
An impulsive Lotka-Volterra type predator-prey model with prey dispersal in two-patch environments and time delays is investigated, where we assume the model Beach Ball of patches with a barrier only as far as the prey population is concerned, whereas the predator population has no barriers between patches.By applying the continuation theorem of co